Identifying causal regulatory variants and their target genes from the majority of non-coding disease-associated genetic loci is the main challenge in post-Genome-Wide Association Studies (GWAS) functional studies.Although chromosome conformation capture (3C) and its derivative technologies have been successfully applied to nominate putative causal
The plasticizer bisphenol A, a typical endocrine disrupting chemical, is widely present in the environment.Previous studies demonstrated that exposure to bisphenol A can cause reproductive toxicity, abnormal fertilization, and infertility.However, the mechanisms of low-concentration bisphenol A on the reproductive system and treatment measures WAX
Magnetic Stove Seal Clip gears are designed to perform in a highly reliable manner, and offer several advantages compared to mechanical gears but difficulties with manufacturing techniques and cost are strong handicaps.In contrast to conventional gears, the contact and lubrication free force transmitting elements lead to a considerable lifetime and
This review summarizes the evidences in the literature on the management of the Brugada syndrome (BS), an arrhythmogenic disease caused by genetic channelopathies, predisposing to syncope and sudden Stove Seal Clip cardiac death in young, apparently healthy, typically male subjects, in the third and fourth decade of their life.Sudden cardiac death